17-AZA-PGF IN2.alpha. XX DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This invention relates to novel prostaglandin F2.alpha.(PGF2.alpha.) derivatives having the general formula (XII) (XII) or a racemate thereof, wherein R1 is hydrogen, lower alkanoyl, trihaloalkanoyl, optionally substituted benzoyl, lower alkoxycarbonyl, lower trihaloalkoxycarbonyl, or optionally sub...

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Bibliographische Detailangaben
Hauptverfasser:	SZEKELY, ISTVAN, VIRAG, SANDOR, SZENTIVANYI, MATYAS, KOVACS, GABOR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	This invention relates to novel prostaglandin F2.alpha.(PGF2.alpha.) derivatives having the general formula (XII) (XII) or a racemate thereof, wherein R1 is hydrogen, lower alkanoyl, trihaloalkanoyl, optionally substituted benzoyl, lower alkoxycarbonyl, lower trihaloalkoxycarbonyl, or optionally substituted phenoxycarbonyl or benzyloxycarbonyl; R2 is hydrogen or alkyl of one to 4 carbon atom(s), R4 is hydrogen or a protecting group; Q is hydrogen, alkyl of one to 4 carbon atom(s) or a pharmaceutically acceptable non-toxic cation. This invention also relates to the racemate consisting of one of the optically active isomers and its mirror image. A process The compounds according to the invention possess valuable prostaglandin-like pharmaceutical activity, are much more effective than natural PGP2.alpha. and show definite .alpha.-adrenergic stimulating activity.