CIS AND TRANS-3-ARYLOXY-4- HYDROXYPYRROLIDINES AND DERIVATIVES THEREOF

CIS AND TRANS-3-ARYLOXY-4- HYDROXYPYRROLIDINES AND DERIVATIVES THEREOF

366 Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: (cis and trans isomers) are disclosed wherein R1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl, R2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-l...

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Bibliographische Detailangaben
Hauptverfasser: WALSH, DAVID A, WELSTEAD, WILLIAM J., JR
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:366 Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: (cis and trans isomers) are disclosed wherein R1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl, R2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and parafluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharmaceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.