METHOD FOR PREPARING SALTS OF (-)CIS-1,2- EPOXYPROPYLPHOSPHONIC ACID

METHOD FOR PREPARING SALTS OF (-)CIS-1,2- EPOXYPROPYLPHOSPHONIC ACID

This invention relates to a novel process for preparing (-)cis-1,2-epoxypropyl phosphoric acid and salts thereof with non-toxic bases. The process comprises oxidising cis-l-propenyl phosphoric acid to produce the corresponding racemic epoxy acid, adding L(+)-threo-l-(p-methylmercaptophenyl)-2-amino-...

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Bibliographische Detailangaben
Hauptverfasser: PORTELLI, MARIO, CERVATO, GIUSEPPE
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention relates to a novel process for preparing (-)cis-1,2-epoxypropyl phosphoric acid and salts thereof with non-toxic bases. The process comprises oxidising cis-l-propenyl phosphoric acid to produce the corresponding racemic epoxy acid, adding L(+)-threo-l-(p-methylmercaptophenyl)-2-amino-1,3-propanediol as a resolving agent, alkalinising the suspension and isolating the acid salt with the base. These products are useful to inhibit the growth of both gram-positive and gramnegative pathogenic bacteria and are used in both the human and veterinary fields. The process, using thiomicamine as the resolving agent, is a more efficient process than the prior art and allows for almost a complete recovery of the resolving agent.