PROSTANOIC ACID DERIVATIVES

PROSTANOIC ACID DERIVATIVES

31/11 PROSTANOIC ACID DERIVATIVES Prostanoic acid derivatives of the formula, ¢I! wherein R1 is hydrogen or C1-4 alkyl, R2 is C4-8 alkyl and is or , are prepared by reacting a cyclopentane of the formula, wherein R2 is defined above and R is hydrogen or tetrahydropyranyl, with Wittig reagent of the...

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Bibliographische Detailangaben
Hauptverfasser: KATSUBE, JUNKI, SUGIE, AKIHIKO, SHIMOMURA, HIROMI
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:31/11 PROSTANOIC ACID DERIVATIVES Prostanoic acid derivatives of the formula, ¢I! wherein R1 is hydrogen or C1-4 alkyl, R2 is C4-8 alkyl and is or , are prepared by reacting a cyclopentane of the formula, wherein R2 is defined above and R is hydrogen or tetrahydropyranyl, with Wittig reagent of the formula, (R3)3P=CH(CH2)3COOM wherein R3 is aryl and M is alkali metal and, if necessary, hydrolyzing, or by oxidizing a compound of the formula, wherein R1 and R2 are as defined above and R9 is tetrahydropyranyl group, with an oxidizing agent. The compounds (I) are useful as anti-ulcer agent.