N-(PHOSPHONOACETYL)-L-ASPARTIC ACID COMPOUNDS AND METHODS FOR THEIR PREPARATION

N-(PHOSPHONOACETYL)-L-ASPARTIC ACID COMPOUNDS AND METHODS FOR THEIR PREPARATION

N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed, These methods include preparation of certain PALA compounds such are PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl P...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHULTZ, ROBERT J, STARKS, FRED W
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed, These methods include preparation of certain PALA compounds such are PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA. The compounds of this invention possess antitumor activity in vivo or are intermediates for the production of active antitumor PALA compounds.