PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS

A process for preparing a 1,2-propylene glycol solvate compound of 7-D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido!-3-(1,2,3-triazol -5-ylthiomethyl)-3-cephem-4-carboxylic acid which comprises dissolving 7-D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido!-3-(1,2,3-triazo l-5-ylthiomethyl)-3-...

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Bibliographische Detailangaben
Hauptverfasser:	FUKUMURA, MASATAKA, TOBIKI, HISAO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A process for preparing a 1,2-propylene glycol solvate compound of 7-D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido!-3-(1,2,3-triazol -5-ylthiomethyl)-3-cephem-4-carboxylic acid which comprises dissolving 7-D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido!-3-(1,2,3-triazo l-5-ylthiomethyl)-3-cephem-4-carboxylic acid or a solvate compound thereof in an acidic 1,2-propylene glycol under substantially anhydrous condition, and neutralizing the resulting solution to precipitate a crystalline 1,2-propylene glycol solvate compound of 7-D-.alpha.-amino-.alpha.(p-hydroxyphenyl)acetamido!-3-(1,2,3-triazol- 5-ylthiomethyl)-3-cephem-4-carboxylic acid. A process for preparing a 1,2-propylene glycol solvate compound of 7-¢D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido!-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid which comprises dissolving 7-¢D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido!-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid or a solvate compound thereof in an acidic 1,2-propylene glycol under substantially anhydrous condition, and neutralizing the resulting solution to precipitate a crystalline 1,2-propylene glycol solvate compound of 7-¢D-.alpha.-amino-.alpha.(p-hydroxyphenyl)acetamido!-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.