THIENO (2,3-D) PYRIMIDINE ANTIALLERGIC AGENTS

THIENO 2,3-D!PYRIMIDINE ANTIALLERGIC AGENTS 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yeilds thieno2,3-d!pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-3-(amino-carbonyl)-4,5,6,7-tetrahydrobenzob!thein-2-yl!oxamic acid, ehtyl 5,6,7,8tetrahydro-4-oxo-4H-benzothieno2,3-d!1,3!oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno2,3-d!pyrimidine-2-carboxylate. THIENO ¢2,3-D!PYRIMIDINE ANTIALLERGIC AGENTS 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yeilds thieno¢2,3-d!pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-¢3-(amino-carbonyl)-4,5,6,7-tetrahydrobenzo¢b!thein-2-yl!oxamic acid, ehtyl 5,6,7,8tetrahydro-4-oxo-4H-benzothieno¢2,3-d!¢1,3!oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno¢2,3-d!pyrimidine-2-carboxylate.