1-SECONDARY AMINO-3-SUBSTITUTED PHENOXY-PROPAN-2-OLS AND PROCESS FOR THEIR PREPARATION

1-Isopropylamino-3-(4- or 2,4-substituted phenoxy)-propan-2-ols of the formula wherein R1 is loweralkyl, R2 is mono(lower)alkylcarbamoylaminoethyl, di(lower)alkylcarbamoylaminoethyl, carbamoyloxy(lower)alkyl, mono(lower)alkylcarbamoyloxy(lower)alkyl, di(lower)alkylcarbamoyloxy(lower)alkyl, carbamoyl...

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Bibliographische Detailangaben
Hauptverfasser:	SJOESTRAND, SVEN E, CARLSSON, ENAR I, SAMUELSSON, BENNY R, BRAENDSTROEM, ARNE E, ABLAD, BENGT A. H, BERNTSSON, PEDER B, CARLSSON, STIG A. I, STRANDLUND, GERT C, EK, LARS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	1-Isopropylamino-3-(4- or 2,4-substituted phenoxy)-propan-2-ols of the formula wherein R1 is loweralkyl, R2 is mono(lower)alkylcarbamoylaminoethyl, di(lower)alkylcarbamoylaminoethyl, carbamoyloxy(lower)alkyl, mono(lower)alkylcarbamoyloxy(lower)alkyl, di(lower)alkylcarbamoyloxy(lower)alkyl, carbamoyloxy(lower)alkoxy, mono(lower)alkylcarbamoyloxy(lower)alkoxy or di(lower)alkylcarbamoyloxy(lower)alkoxy, and R3 is hydrogen or halogen; are described as new compounds possessing valuable pharmacological properties. They block cardiac and vascular .beta.-receptors and can be used as cardioselective antagonists of adrenergic .beta.-receptor-stimulators, e.g. in the treatment of arrhythmias and angina pectoris. A process for the preparation of the new compounds is also described.