STEROIDS

STEROIDS

This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is particularly concerned with the production of such steroids having an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TORABI, HOUSHANG, MORROW, DUANE F, LEVINSKY, HENRY L
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is particularly concerned with the production of such steroids having anti-inflammatory action, e.g. beclomethasone dipropionate. There is disclosed a new route for preparing 9.alpha.halo-11.beta.-hydroxy-corticosteroids which involves the formation of novel 9.beta.,11.beta.-epoxy steroids which themselves may be conveniently obtained from the corresponding 9.alpha.-bromo-11.beta.-hydroxy-corticosteroids.