ANTIBIOTICS SF-1771 FROM STREPTOMYCES

ANTIBIOTICS SF-1771 FROM STREPTOMYCES

A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomvces tovocaensis SF-1771 in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorp...

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Bibliographische Detailangaben
Hauptverfasser: SHOMURA, TAKASHI, OHBA, KAZUNORI, NIIDA, TARO, WATANABE, HIROSHI, TOTSUKAWA, KUNIKAZU, KOJIMA, MICHIO, OMOTO, SHOJI, INOUE, SHIGEHARU, TSURUOKA, TAKASHI
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomvces tovocaensis SF-1771 in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing ` antibiotic which shows antibacterial activity to Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a lower toxicity than SF-1771 substance.