PHENYLALKYLAMINES
The invention relates to novel phenylalkylamines of formula I wherein R1 represents a hydrogen atom, the group -(CH)n-R4 (wherein n is 1 or 2 and R4 represents a hydrogen atom, or a cyano or benzoyl group) or the group-CO-R5 (wherein R5 represents a hydrogen atom, a lower alkoxy group, a benzoyl or...
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Sprache: | eng ; fre |
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Zusammenfassung: | The invention relates to novel phenylalkylamines of formula I wherein R1 represents a hydrogen atom, the group -(CH)n-R4 (wherein n is 1 or 2 and R4 represents a hydrogen atom, or a cyano or benzoyl group) or the group-CO-R5 (wherein R5 represents a hydrogen atom, a lower alkoxy group, a benzoyl or benzyloxy group, or a group of the formula -CH2-NH2, -CH(CH3)-NH2,-CH2-NH-CH2-C6H5 or -CH(CH3)-NH-CH2-C6H5); and R3 represents an amino group or a group -NH-CO-R6 (wherein R6 represents a hydrogen atom, a methyl, methoxy, ethoxy, methylthio or ethylthio group) or a group -NH-W-R7 (wherein R7 represents an amino, methylamino or dimethylamino group and W represents the group-CO- or SO2). The invention also relates to the acid addition salts thereof as well as to processes for their preparation. The novel compounds possess interesting physiological activity and in particular are sympa?homimetically active and exhibit an activity on the central nervous system. The novel compounds are thus potentially useful as stabilizers of the circulation and have been found to cause a long-lasting increase in blood pressure. Processes for the production of the novel compounds are described and examples of certain of the novel compounds are given. Pharmaceutical compositions containing the novel compounds are described and exemplified. ! |
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