PROCEDURE FOR PREPARING DERIVATIVES OF THIENODIAZOEPINONE

PROCEDURE FOR PREPARING DERIVATIVES OF THIENODIAZOEPINONE

The present invention relates to thiene diazoepinone derivatives useful as pharmacological agents having the formula (I) wherein each of R1 and R2 is a hydrogen atom, a straight or branch chain alkyl radical having 1 to 4 carbon atoms or R1 and R2 together form a tetramethylene chain and R3 is a phe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TAPIA, ALVARO GARCIA, BRANA, MIGUEL FERNANDEZ, ROLDAN, CRISTOBAL MARTINEZ, ZAMBRANA, JOAQUIN DEL RIO, BARRACHINA, ANTONIO VILA CORO, PELAEZ, RAMON MADRONERO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to thiene diazoepinone derivatives useful as pharmacological agents having the formula (I) wherein each of R1 and R2 is a hydrogen atom, a straight or branch chain alkyl radical having 1 to 4 carbon atoms or R1 and R2 together form a tetramethylene chain and R3 is a phenyl group which may be substituted by a chloro nitro or trichloromethyl group or a pharmaceutically acceptable salt. The compounds may be prepared by reacting a 2-amino-3-aroyl-thiopene of the formula wherein R1, R2 and R3 are as above with oxazolidine-2,5-dione in the presence of hydrogen chloride and a solvent.