AMINES AND PROCESS FOR THEIR PREPARATION

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R1 is alkyl or hydroxy alkyl, R2 is alkoxyalkyl, alkylthioalkyl, alkoxycarbonylaminoalkyl, or alkoxyalkoxy, and R3 is halogen, alkyl, alkenyl,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SJOESTRAND, SVEN E, CARLSSON, ENAR I, SAMUELSSON, BENNY R, ABLAD, BENGT A.H, BRAENDSTROEM, ARNE E, BERNTSSON, PEDER B, CARLSSON, STIG A. I, STRANDLUND, GERT C, EK, LARS
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R1 is alkyl or hydroxy alkyl, R2 is alkoxyalkyl, alkylthioalkyl, alkoxycarbonylaminoalkyl, or alkoxyalkoxy, and R3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed as are methods for their preparations; Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the beta -receptors of the heart making them useful in treating heart diseases in animals including humans.