DIBENZOCYCLOHEPTENYL LACTAMIMIDES

1421058 Dibenzocycloheptenyl lactamimides RICHARDSON-MERRELL Inc 28 Nov 1973 [5 Jan 1973] 55212/73 Heading C2C Novel compounds of the Formula (I): wherein n is an integer of from 3 to 11, and pharmaceutically acceptable acid addition salts thereof, may be obtained by reacting 10,11- dihydro - 5H - dibenzo[a,d]cyclohepten - 5- amine with an excess of a lactim ether of the formula where the alkyl may be methyl, ethyl or the like, or with a complex of a corresponding lactam with phosphorous oxychloride, phosgene, boron trifluoride etherate, dimethyl sulphate, hydrogen halide or a combination of two or more of these reagents. Pharmaceutical compositions useful as diuretics, anti-inflammatory agents or anticoagulants, comprise a compound of Formula I, and a pharmaceutical carrier, in forms suitable for oral or parenteral use.