compostos derivados de aminobutíricos substituidos como inibidores de neprilisina, uso dos mesmos, composição farmacêutica, combinação e método para inibição de atividade endopeptidase neutra

The present invention provides a compound of formula I'; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention...

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Bibliographische Detailangaben
Hauptverfasser: Rajeshri Ganesh Karki, Toshio Kawanami, Gary Mark Coppola, Gary Michael Ksander, Muneto Mogi, Yuki Iwaki
Format: Patent
Sprache:por
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Zusammenfassung:The present invention provides a compound of formula I'; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.