seqüências geneticamente modificadas de antígenos de plasmodium vivax, composições vacinais contendo proteínas recombinantes e vírus recombinantes que expressam esses antígenos e método de vacinação dose-reforço contra malária

The present invention relates to the construction of modified genetic sequences, which comprise sequences for antigens (DBP-PA, DBP-AM, DBP-MT, AMA-1, CS and MSP-1 ) of Plasmodium vivax, the corresponding recombinant proteins encoded by said sequences as well as genetically modified viruses that exp...

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Bibliographische Detailangaben
Hauptverfasser:	FLÁVIO DA FONSECA GUIMARÃES, MAURÍIO MARTINS RODRIGUES, IRENE SOARES, OSCAR BRUNA ROMERO, MARISA CRISTINA DA FONSECA, LEONEIDE ERICA MADURO BOUILLET, CRISTINA LIMA CARRARA, RICARDO TOSTES GAZZINELLI, BRUNA DE ANDRADE PEREIRA, CRISTIANA FERREIRA ALVES DE BRITO
Format:	Patent
Sprache:	por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the construction of modified genetic sequences, which comprise sequences for antigens (DBP-PA, DBP-AM, DBP-MT, AMA-1, CS and MSP-1 ) of Plasmodium vivax, the corresponding recombinant proteins encoded by said sequences as well as genetically modified viruses that express these recombinant antigens. In addition, the present invention refers to a method of prime-boost vaccination using adenoviral or poxviral vectors, purified proteins for immunization of mammals and vaccine compositions to be used as vaccines against malaria.