método para a filtração de um líquido de biorreator, módulo de membrana de fluxo cruzado, sistema de biorreator de membrana, e, uso de um fluxo descendente de líquido de um líquido de biorreator

The invention provides a method for the filtration of a bioreactor liquid (10) from a bioreactor (1) with a cross-flow membrane module (20) comprising one or more membranes (40). The method comprises feeding part of the bioreactor liquid (10) to a liquid inlet (21) of the cross-flow membrane module (20), transporting the bioreactor liquid (10) through the cross-flow membrane module (20) in a cross-flow mode, and removing a retentate (12) from a liquid outlet (22) of the cross-flow membrane module (20). The cross-flow membrane module (20) is arranged to allow a liquid downward flow of the bioreactor liquid (10) through the cross-flow membrane module (20). The method further comprises providing the liquid downward flow and a downward gas flow of a gas (30) through the cross-flow membrane module (20). Fouling of the membranes is relatively good prevented or reduced in time. Further, the liquid flow may be reduced relative to conventional configurations.