composto, composição farmacêutica e usos de um composto
In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compou...
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| creator | ANDREW M. PETROS LISA A. HASVOLD PETER COLMAN KEITH GEOFFREY WATSON GEORGE NIKOLAKOPOULOS ANDREW J. SOUERS DANETTE A. DUDLEY JONATHAN BAYLDON BAELL STEVEN W. ELMORE GUILLAUME LAURENT LESSENE CHUDI NDUBAKU LE WANG ZHI-FU TAO KURT DESHAYES PETER CZABOTAR XILU WANG BRAD EDMUND SLEEBS WAYNE J. FAIRBROTHER JOHN A. FLYGARE CHINH THIEN BUI BRIAN JOHN SMITH |
| description | In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins. |
| format | Patent |
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ELMORE ; GUILLAUME LAURENT LESSENE ; CHUDI NDUBAKU ; LE WANG ; ZHI-FU TAO ; KURT DESHAYES ; PETER CZABOTAR ; XILU WANG ; BRAD EDMUND SLEEBS ; WAYNE J. FAIRBROTHER ; JOHN A. FLYGARE ; CHINH THIEN BUI ; BRIAN JOHN SMITH</creator><creatorcontrib>ANDREW M. PETROS ; LISA A. HASVOLD ; PETER COLMAN ; KEITH GEOFFREY WATSON ; GEORGE NIKOLAKOPOULOS ; ANDREW J. SOUERS ; DANETTE A. DUDLEY ; JONATHAN BAYLDON BAELL ; STEVEN W. ELMORE ; GUILLAUME LAURENT LESSENE ; CHUDI NDUBAKU ; LE WANG ; ZHI-FU TAO ; KURT DESHAYES ; PETER CZABOTAR ; XILU WANG ; BRAD EDMUND SLEEBS ; WAYNE J. FAIRBROTHER ; JOHN A. FLYGARE ; CHINH THIEN BUI ; BRIAN JOHN SMITH</creatorcontrib><description>In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.</description><language>por</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; TRAPPING</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171010&DB=EPODOC&CC=BR&NR=PI0918360A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171010&DB=EPODOC&CC=BR&NR=PI0918360A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ANDREW M. 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In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBKzs8tyC8uyddRgLAyDy8_vDhfIS2xKDcx-fCq0pLM5ESFVIXS4vxihRQgnasA08HDwJqWmFOcyguluRmU3FxDnD10Uwvy41OLCxKTU_NSS-KdggI8DSwNLYzNDByNjIlSBADn-jHp</recordid><startdate>20171010</startdate><enddate>20171010</enddate><creator>ANDREW M. 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FLYGARE</creatorcontrib><creatorcontrib>CHINH THIEN BUI</creatorcontrib><creatorcontrib>BRIAN JOHN SMITH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ANDREW M. PETROS</au><au>LISA A. HASVOLD</au><au>PETER COLMAN</au><au>KEITH GEOFFREY WATSON</au><au>GEORGE NIKOLAKOPOULOS</au><au>ANDREW J. SOUERS</au><au>DANETTE A. DUDLEY</au><au>JONATHAN BAYLDON BAELL</au><au>STEVEN W. ELMORE</au><au>GUILLAUME LAURENT LESSENE</au><au>CHUDI NDUBAKU</au><au>LE WANG</au><au>ZHI-FU TAO</au><au>KURT DESHAYES</au><au>PETER CZABOTAR</au><au>XILU WANG</au><au>BRAD EDMUND SLEEBS</au><au>WAYNE J. FAIRBROTHER</au><au>JOHN A. FLYGARE</au><au>CHINH THIEN BUI</au><au>BRIAN JOHN SMITH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>composto, composição farmacêutica e usos de um composto</title><date>2017-10-10</date><risdate>2017</risdate><abstract>In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING |
| title | composto, composição farmacêutica e usos de um composto |
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