composto, composição farmacêutica e usos de um composto

In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compou...

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Bibliographische Detailangaben
Hauptverfasser:	ANDREW M. PETROS, LISA A. HASVOLD, PETER COLMAN, KEITH GEOFFREY WATSON, GEORGE NIKOLAKOPOULOS, ANDREW J. SOUERS, DANETTE A. DUDLEY, JONATHAN BAYLDON BAELL, STEVEN W. ELMORE, GUILLAUME LAURENT LESSENE, CHUDI NDUBAKU, LE WANG, ZHI-FU TAO, KURT DESHAYES, PETER CZABOTAR, XILU WANG, BRAD EDMUND SLEEBS, WAYNE J. FAIRBROTHER, JOHN A. FLYGARE, CHINH THIEN BUI, BRIAN JOHN SMITH
Format:	Patent
Sprache:	por
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.