polipeptídeos de fator ix modificados e usos dos mesmos

polipeptídeos de fator ix modificados e usos dos mesmos

Disclosed are modified Factor IX polypeptides such as Factor IX polypeptides with one or more introduced glycosylation sites. The modified Factor IX polypeptides may exhibit increased in vitro or in vivo stability such as a longer plasma half-life. Also, methods are disclosed of making modified Fact...

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Bibliographische Detailangaben
Hauptverfasser: JOHN E. MURPHY, CHANDRA PATEL, MARIAN SETO, KORNELIA KIRCHNER, ULRICH HAUPTS, UWE GRITZAN, XIAOQIAO JIANG, ALAN BROOKS
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Disclosed are modified Factor IX polypeptides such as Factor IX polypeptides with one or more introduced glycosylation sites. The modified Factor IX polypeptides may exhibit increased in vitro or in vivo stability such as a longer plasma half-life. Also, methods are disclosed of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.