Derivado esteroide de gama-lactona de ácido 17-hidróxi-19-nor-21-carboxílico, uso do mesmo e medicamento que contém o derivado

The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the chemical formula I, where R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the...

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Hauptverfasser: HANS PETER MUHN, STEFFEN BORDEN, FREDERIK MENGES, KATJA PRELLE, THOMAS FRENZEL, ROLF BOHLMANN, SVEN RING, JAN HÜBNER, ULRICH KLAR, JOACHIM KUHNKE
Format: Patent
Sprache:por
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Zusammenfassung:The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the chemical formula I, where R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.