Métodos para a inibição de cicatrização

The invention provides new methods of treatment using anti-scarring agents to inhibit scarring in humans, and also provides anti-scarring agents for new uses in the inhibition of scarring in humans. In a first incidence of treatment an anti-scarring agent is provided to each centimetre of a wound ma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHARON O'KANE, ADAM BOANAS, MARK WILLIAN JAMES FERGUSON, KERRY NIELD, NICHOLAS OCCLESTON, KATE OWEN, ABDUL SATTAR, JAMES BUSH, NICHOLAS GOLDSPINK
Format: Patent
Sprache:por
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Beschreibung
Zusammenfassung:The invention provides new methods of treatment using anti-scarring agents to inhibit scarring in humans, and also provides anti-scarring agents for new uses in the inhibition of scarring in humans. In a first incidence of treatment an anti-scarring agent is provided to each centimetre of a wound margin or each centimetre of a site at which a wound is to be formed in a first therapeutically effective amount; and in a subsequent incidence of treatment the anti-scarring agent is provided to each centimetre of wound margin in a larger therapeutically effective amount. The incidences of treatment occur between 8 hours and 48 hours apart from one another. The anti-scarring agent is preferably not TGF- 3. The anti-scarring agent may be provided by intradermal N injection. Also provided are kits and methods of selecting an appropriate treatment regime for inhibiting scarring associated with the healing of a human wound.