Protease, método para o tratamento de doenças, e, uso de uma protease

The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with...

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Bibliographische Detailangaben
Hauptverfasser: ALLAN SVENDSEN, PETER COLIN GREGORY, SIGNE ESKILDSEN LARSEN, THOMAS LENHARD, LARS BEIER, TANJA MARIA ROSENKILDE KJAER
Format: Patent
Sprache:por
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Zusammenfassung:The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.