Diaminas unidas ou fusionadas substituídas com arila como moduladoras de leucotrieno a4 hidrolase

Diaminas unidas ou fusionadas substituídas com arila como moduladoras de leucotrieno a4 hidrolase

Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediate...

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Hauptverfasser: MATTHEW T. EPPERSON, ALEJANDRO SANTILLAN, LAURENT GOMEZ, GENESIS M. BACANI, JR, KELLY J. MCCLURE, AARON M. KEARNEY, WENDY ECCLES, SCOTT D. BEMBENEK, CHERYL A. GRICE, JAMES P. EDWARDS, ADRIENNE M. LANDRY-BAYLE, ALICE LEE-DUTRA, TARANEH MIRZADEGAN
Format: Patent
Sprache:por
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.