MODULAÇÃO DE RECEPTORES QUIMIOSSENSORES E LIGANTES ASSOCIADOS COM ELES

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of...

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Bibliographische Detailangaben
Hauptverfasser:	XIAO-QING TANG, XIAODONG LI, VINCENT DARMOHUSODO, SARA ADAMSKI-WERNER, GUY SERVANT, JEFFREY ROBERT HAMMAKER, HONG ZHANG, XINSHAN KANG, BORIS KLEBANSKY, RICHARD FINE, CATHERINE TACHDJIAN, ALBERT ZLOTNIK, JEFFREY YAMAMOTO, HAITIAN LIU, RACHEL D.A. KIMMICH, DONALD S. KARANEWSKY, QING CHEN, FENG ZHANG, GORAN PETROVIC, MARKETA RINNOVA, MARK ZOLLER, JOSEPH R. FOTSING
Format:	Patent
Sprache:	por
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL TESTING THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention includes processes for preparing the modifiers of chemosensory receptors and their ligands.