COMPOSIÇÕES E MÉTODOS RELACIONADOS A CÉLULA-TRONCO CD34

The invention relates to CD34- stem cells for use as a medicament in the treatment of a subject afflicted with a gastrointestinal disorder. The invention relates to genetically modified CD34- stem cells, wherein each of the genetically modified CD34- stem cells contains an exogenous nucleic acid com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MATTHIAS C. RAGGI, RALF HUSS, PETER NELSON, MANFRED J. STANGL
Format:	Patent
Sprache:	por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to CD34- stem cells for use as a medicament in the treatment of a subject afflicted with a gastrointestinal disorder. The invention relates to genetically modified CD34- stem cells, wherein each of the genetically modified CD34- stem cells contains an exogenous nucleic acid comprising (i) a region encoding a protein which enhances endothelial cell growth, which region is operably linked to (ii) an endothelium-specific promoter or promoter/enhancer combination, and CD34- stem cells without genetic modification. In a preferred embodiment of the invention the cells and medical use thereof are characterised in that the introduction of the CD34-stem cells is not preceded, accompanied or followed by myeloablation.