TITULAÇÕES DE POLIPEPTÍDEO DO FATOR VIII EM CULTURAS DE CÉLULAS

TITULAÇÕES DE POLIPEPTÍDEO DO FATOR VIII EM CULTURAS DE CÉLULAS

The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a Factor VIII polypeptide under conditions for expression of said Factor VIII polypeptide, said culturing conditions involving a cell culture...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GERT BOLT, LAUST BRUUN JOHNSEN, THOMAS DOCK STEENSTRUP, IDA HILDEN
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a Factor VIII polypeptide under conditions for expression of said Factor VIII polypeptide, said culturing conditions involving a cell culture medium comprising a C2-domain ligand, and b) isolating the expressed Factor VIII polypeptide from the mammalian cell by suitable means.