ANTICORPOS HUMANOS QUE SE LIGAM A IL-12 HUMANA E MÉTODOS PARA PRODUÇÃO

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12 ) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an...

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Bibliographische Detailangaben
Hauptverfasser:	MICHAEL PASKIND, AMY VENTURINI, SARAH LEILA DU FOU, ANGELA WIDOM, JOCHEN G. SALFELD, BORIS LABKOVSKY, SARA CARMEN, SUBHASHIS BANERJEE, GEERTRUIDA M. VELDMAN, JOHN GAWAIN ELVIN, THOR LAS HOLTET, STEPHEN SMITH, DANIEL EDWARD TRACEY, MICHAEL WHITE, NICHOLAS W. WARNE, ELAINE J. DERBYSHIRE, ZEHRA KAYMAKCALAN, ALEXANDER ROBERT DUNCAN, STUART FRIEDRICH, MICHAEL ROGUSKA, PAUL SAKORAFAS, ANGELA MYLES
Format:	Patent
Sprache:	por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12 ) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.