processo para preparar um composto

"PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6naftiridin-6(5H )-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i1 !-amina e seu sal de succinat...

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Hauptverfasser:	DONGWEI CAI, MIN GE, FRED FLEITZ, ELIZABETH SZUMIGALA, CHANGYOU ZHOU, SCOTT HOERRNER, ROBERT LARSEN, WENJIE LI, LIHU YANG, GARY JAVADI, DORIAN NELSON, MARK JENSEN
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Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	DONGWEI CAI MIN GE FRED FLEITZ ELIZABETH SZUMIGALA CHANGYOU ZHOU SCOTT HOERRNER ROBERT LARSEN WENJIE LI LIHU YANG GARY JAVADI DORIAN NELSON MARK JENSEN
description	"PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6naftiridin-6(5H )-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i1 !-amina e seu sal de succinato. A presente invenção adicionalmente proporciona uma sintese eficiente para a preparação de intermediários (3R)-3metóxi-tetra-hidro-4H-piran-4-ona; ácido (lS,4S)-4-(2,5-dimeti1-1H-pirro1-1i1)-1-isopropi1-ciclo-pent-2-eno-1-c arboxílico; e 3-(trifluorometi1)-5,6,7,8tetra-hidro-1,6-naftiridina; e para a preparação do precursor (3S,4S)-N((1S,4S)-4-isopropi1-4-{¢3-trifluorometi1)-7,8-di-hidro-1,6-na ftiridin-6(5H)i1!-carboni1}-ciclo-pent-2-en-1-i1)-3-metóxi-tetra-hidro-2 H-piran-4-amina. A invenção adicionalmente reside nas propriedades superiores do sal de succinato de ((1R,3S)-3-isopropi1-3-{¢3-(trifluorometi1)-7,8-di-hidro-1,6naftiridin-6(5 H)-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i 1!-amina. The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine
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fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_BRPI0415862A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>BRPI0415862A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_BRPI0415862A3</originalsourceid><addsrcrecordid>eNrjZFAqKMpPTi0uzlcoSCxKVCgoSgXRRQqluQrJ-bkF-cUl-TwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN4pKMDTwMTQ1MLMyNGYGDUA3DAmug</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>processo para preparar um composto</title><source>esp@cenet</source><creator>DONGWEI CAI ; MIN GE ; FRED FLEITZ ; ELIZABETH SZUMIGALA ; CHANGYOU ZHOU ; SCOTT HOERRNER ; ROBERT LARSEN ; WENJIE LI ; LIHU YANG ; GARY JAVADI ; DORIAN NELSON ; MARK JENSEN</creator><creatorcontrib>DONGWEI CAI ; MIN GE ; FRED FLEITZ ; ELIZABETH SZUMIGALA ; CHANGYOU ZHOU ; SCOTT HOERRNER ; ROBERT LARSEN ; WENJIE LI ; LIHU YANG ; GARY JAVADI ; DORIAN NELSON ; MARK JENSEN</creatorcontrib><description>"PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6naftiridin-6(5H )-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i1 !-amina e seu sal de succinato. A presente invenção adicionalmente proporciona uma sintese eficiente para a preparação de intermediários (3R)-3metóxi-tetra-hidro-4H-piran-4-ona; ácido (lS,4S)-4-(2,5-dimeti1-1H-pirro1-1i1)-1-isopropi1-ciclo-pent-2-eno-1-c arboxílico; e 3-(trifluorometi1)-5,6,7,8tetra-hidro-1,6-naftiridina; e para a preparação do precursor (3S,4S)-N((1S,4S)-4-isopropi1-4-{¢3-trifluorometi1)-7,8-di-hidro-1,6-na ftiridin-6(5H)i1!-carboni1}-ciclo-pent-2-en-1-i1)-3-metóxi-tetra-hidro-2 H-piran-4-amina. A invenção adicionalmente reside nas propriedades superiores do sal de succinato de ((1R,3S)-3-isopropi1-3-{¢3-(trifluorometi1)-7,8-di-hidro-1,6naftiridin-6(5 H)-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i 1!-amina. The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine</description><edition>7</edition><language>por</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070109&DB=EPODOC&CC=BR&NR=PI0415862A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070109&DB=EPODOC&CC=BR&NR=PI0415862A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DONGWEI CAI</creatorcontrib><creatorcontrib>MIN GE</creatorcontrib><creatorcontrib>FRED FLEITZ</creatorcontrib><creatorcontrib>ELIZABETH SZUMIGALA</creatorcontrib><creatorcontrib>CHANGYOU ZHOU</creatorcontrib><creatorcontrib>SCOTT HOERRNER</creatorcontrib><creatorcontrib>ROBERT LARSEN</creatorcontrib><creatorcontrib>WENJIE LI</creatorcontrib><creatorcontrib>LIHU YANG</creatorcontrib><creatorcontrib>GARY JAVADI</creatorcontrib><creatorcontrib>DORIAN NELSON</creatorcontrib><creatorcontrib>MARK JENSEN</creatorcontrib><title>processo para preparar um composto</title><description>"PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6naftiridin-6(5H )-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i1 !-amina e seu sal de succinato. A presente invenção adicionalmente proporciona uma sintese eficiente para a preparação de intermediários (3R)-3metóxi-tetra-hidro-4H-piran-4-ona; ácido (lS,4S)-4-(2,5-dimeti1-1H-pirro1-1i1)-1-isopropi1-ciclo-pent-2-eno-1-c arboxílico; e 3-(trifluorometi1)-5,6,7,8tetra-hidro-1,6-naftiridina; e para a preparação do precursor (3S,4S)-N((1S,4S)-4-isopropi1-4-{¢3-trifluorometi1)-7,8-di-hidro-1,6-na ftiridin-6(5H)i1!-carboni1}-ciclo-pent-2-en-1-i1)-3-metóxi-tetra-hidro-2 H-piran-4-amina. A invenção adicionalmente reside nas propriedades superiores do sal de succinato de ((1R,3S)-3-isopropi1-3-{¢3-(trifluorometi1)-7,8-di-hidro-1,6naftiridin-6(5 H)-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i 1!-amina. The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAqKMpPTi0uzlcoSCxKVCgoSgXRRQqluQrJ-bkF-cUl-TwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN4pKMDTwMTQ1MLMyNGYGDUA3DAmug</recordid><startdate>20070109</startdate><enddate>20070109</enddate><creator>DONGWEI CAI</creator><creator>MIN GE</creator><creator>FRED FLEITZ</creator><creator>ELIZABETH SZUMIGALA</creator><creator>CHANGYOU ZHOU</creator><creator>SCOTT HOERRNER</creator><creator>ROBERT LARSEN</creator><creator>WENJIE LI</creator><creator>LIHU YANG</creator><creator>GARY JAVADI</creator><creator>DORIAN NELSON</creator><creator>MARK JENSEN</creator><scope>EVB</scope></search><sort><creationdate>20070109</creationdate><title>processo para preparar um composto</title><author>DONGWEI CAI ; MIN GE ; FRED FLEITZ ; ELIZABETH SZUMIGALA ; CHANGYOU ZHOU ; SCOTT HOERRNER ; ROBERT LARSEN ; WENJIE LI ; LIHU YANG ; GARY JAVADI ; DORIAN NELSON ; MARK JENSEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0415862A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2007</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>DONGWEI CAI</creatorcontrib><creatorcontrib>MIN GE</creatorcontrib><creatorcontrib>FRED FLEITZ</creatorcontrib><creatorcontrib>ELIZABETH SZUMIGALA</creatorcontrib><creatorcontrib>CHANGYOU ZHOU</creatorcontrib><creatorcontrib>SCOTT HOERRNER</creatorcontrib><creatorcontrib>ROBERT LARSEN</creatorcontrib><creatorcontrib>WENJIE LI</creatorcontrib><creatorcontrib>LIHU YANG</creatorcontrib><creatorcontrib>GARY JAVADI</creatorcontrib><creatorcontrib>DORIAN NELSON</creatorcontrib><creatorcontrib>MARK JENSEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DONGWEI CAI</au><au>MIN GE</au><au>FRED FLEITZ</au><au>ELIZABETH SZUMIGALA</au><au>CHANGYOU ZHOU</au><au>SCOTT HOERRNER</au><au>ROBERT LARSEN</au><au>WENJIE LI</au><au>LIHU YANG</au><au>GARY JAVADI</au><au>DORIAN NELSON</au><au>MARK JENSEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>processo para preparar um composto</title><date>2007-01-09</date><risdate>2007</risdate><abstract>"PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6naftiridin-6(5H )-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i1 !-amina e seu sal de succinato. A presente invenção adicionalmente proporciona uma sintese eficiente para a preparação de intermediários (3R)-3metóxi-tetra-hidro-4H-piran-4-ona; ácido (lS,4S)-4-(2,5-dimeti1-1H-pirro1-1i1)-1-isopropi1-ciclo-pent-2-eno-1-c arboxílico; e 3-(trifluorometi1)-5,6,7,8tetra-hidro-1,6-naftiridina; e para a preparação do precursor (3S,4S)-N((1S,4S)-4-isopropi1-4-{¢3-trifluorometi1)-7,8-di-hidro-1,6-na ftiridin-6(5H)i1!-carboni1}-ciclo-pent-2-en-1-i1)-3-metóxi-tetra-hidro-2 H-piran-4-amina. A invenção adicionalmente reside nas propriedades superiores do sal de succinato de ((1R,3S)-3-isopropi1-3-{¢3-(trifluorometi1)-7,8-di-hidro-1,6naftiridin-6(5 H)-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i 1!-amina. The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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title	processo para preparar um composto
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