processo para preparar um composto

"PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6naftiridin-6(5H )-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i1 !-amina e seu sal de succinato. A presente invenção adicionalmente proporciona uma sintese eficiente para a preparação de intermediários (3R)-3metóxi-tetra-hidro-4H-piran-4-ona; ácido (lS,4S)-4-(2,5-dimeti1-1H-pirro1-1i1)-1-isopropi1-ciclo-pent-2-eno-1-c arboxílico; e 3-(trifluorometi1)-5,6,7,8tetra-hidro-1,6-naftiridina; e para a preparação do precursor (3S,4S)-N((1S,4S)-4-isopropi1-4-{¢3-trifluorometi1)-7,8-di-hidro-1,6-na ftiridin-6(5H)i1!-carboni1}-ciclo-pent-2-en-1-i1)-3-metóxi-tetra-hidro-2 H-piran-4-amina. A invenção adicionalmente reside nas propriedades superiores do sal de succinato de ((1R,3S)-3-isopropi1-3-{¢3-(trifluorometi1)-7,8-di-hidro-1,6naftiridin-6(5 H)-i1!-carboni1}-ciclo-penti1)¢(3S,4S)-3-metóxi-tetra-hidro-2Hpiran-4-i 1!-amina. The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine