COMPOSTO,FORMULACAO FARMACEUTICA,PROCESSO PARA PREPARAR UM COMPOSTO E COMPOSTO OBTIDO

COMPOSTO,FORMULACAO FARMACEUTICA,PROCESSO PARA PREPARAR UM COMPOSTO E COMPOSTO OBTIDO

This invention relates to N-[2-amino-4-substituted-[[(pyrrolo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acid compounds of formula wherein Ar is dihydropyrrolo, pyrrolo, pyrido or tetrahydropyrido; R is hydrogen, chloro, alkylthio, alkoxy, alkylamino, or dialkylamino; and R is C2-C3 alk...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHUAH SHIH, LYNN STACY GOSSETT
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention relates to N-[2-amino-4-substituted-[[(pyrrolo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acid compounds of formula wherein Ar is dihydropyrrolo, pyrrolo, pyrido or tetrahydropyrido; R is hydrogen, chloro, alkylthio, alkoxy, alkylamino, or dialkylamino; and R is C2-C3 alkyl intermediates for their synthesis, pharmaceutical formulations containing those compounds, and their use as antineoplastic agents.