MÉTODOS DE PREPARO, MÉTODO DE PURIFICAÇÃO, E COMPOSTO

MÉTODOS DE PREPARO, MÉTODO DE PURIFICAÇÃO, E COMPOSTO

São fornecidos na presente invenção formulações, processos, formas sólidas e métodos de uso relativos a 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metil-ciclo-hexilamino)-pirimidina-5-carboxamida. The invention provides a method of preparing compound of formula (iv),by contacting the compound of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: NANFEI ZHOU, HON-WAH MAN, JALE MUSLEHIDDINOGLU, MOHIT ATUL KOTHARE, NATHAN ANDREW BOERSEN, LIANFENG HUANG, JEAN XU, MARIE GEORGES BEAUCHAMPS, MARK A. NAGY, ANTONIO CHRISTIAN FERRETTI, KELVIN HIN-YEONG YONG, DAOZHONG ZOU, YING LI, ROBERT HILGRAF
Format: Patent
Sprache:por
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:São fornecidos na presente invenção formulações, processos, formas sólidas e métodos de uso relativos a 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metil-ciclo-hexilamino)-pirimidina-5-carboxamida. The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is substituted or unsubstituted C1-8 alkyl, or substituted saturated cycloalkyl as defined herein.