processo para a preparação de drospirenona

processo para a preparação de drospirenona

ÿþr A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p-dimethylene-5p-androstane-3p,5,17p-triol (II) or 3 ,5̂iÎ ̂-6 ,7 ;15 ,16 -dimethylene-5 ,17α-pregnane-21,17-carbolactone (III) as starting material, through a single-step reaction it is obtained drospirenone (I), a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ROBERTO LENNA, MARIA GIOVANNA LUONI, MONICA NOSEDA, FRANCESCO BARBIERI
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:ÿþr A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p-dimethylene-5p-androstane-3p,5,17p-triol (II) or 3 ,5̂iÎ ̂-6 ,7 ;15 ,16 -dimethylene-5 ,17α-pregnane-21,17-carbolactone (III) as starting material, through a single-step reaction it is obtained drospirenone (I), a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action.