processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona

processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)- 7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1- il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona” métodos de processo de fabricação de inibidor dual mtor/pi3k gdc-0980, denomin...

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Hauptverfasser:	ZHIGANG CHENG, QINGPING TIAN, REINHARD REENTS, SRINIVASAN BABU, PIRMIN HIDBER, FRANCIS GOSSELIN, THERESA HUMPHRIES, HERBERT YAJIMA, URSULA HOFFMANN
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)- 7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1- il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona” métodos de processo de fabricação de inibidor dual mtor/pi3k gdc-0980, denominado (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4- morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona, e estereoisômeros, isômeros geométricos, tautômeros e sais farmaceuticamente aceitáveis destes. Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.