derivados de imidazopirazina como moduladores da atividade

A series of imidazo[1,2-α]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive...

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Bibliographische Detailangaben
Hauptverfasser:	DEBORAH LEIGH, JAMES MADDEN, JOHN ROBERT PORTER, LAURA JANE GLEAVE, ZHAONING ZHU, THOMAS PAUL CAIN, ALEXANDER HEIFETZ, DANIEL CHRISTOPHER BROOKINGS, CRAIG JOHNSTONE, VICTORIA ELIZABETH JACKSON, JULIEN ALISTAIR BROWN, MATTHEW DUNCAN SELBY, JONATHAN MARK BENTLEY
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A series of imidazo[1,2-α]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorder; and oncological disorders.