derivados de imidazopiridina como moduladores da atividade de tnf

A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain...

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Hauptverfasser:	JAMES THOMAS REUBERSON, FABIEN CLAUDE LECOMTE, DEBORAH LEIGH, JAMES MADDEN, JOHN ROBERT PORTER, LAURA JANE GLEAVE, MARTIN ALEXANDER LOWE, SARAH EMILY RICHARDSON, THOMAS PAUL CAIN, PRAFUL TULSHI CHOVATIA, JULIEN ALISTAIR BROWN, MATTHEW DUNCAN SELBY, JONATHAN MARK BENTLEY, MARTIN CLIVE HUTCHINGS, LAURA CLAIRE REED, ZHAONING ZHU, BORIS KROEPLIEN, ELLEN OLIVIA GALLIMORE, ALEXANDER HEIFETZ, JAMES ANDREW JOHNSON, DANIEL CHRISTOPHER BROOKINGS, JOANNA RACHEL QUINCEY, CRAIG JOHNSTONE, HELEN TRACEY HORSLEY, VICTORIA ELIZABETH JACKSON, ANNE MARIE FOLEY, MICHAEL ALAN SHAW, ANTHONY JOHN RICHARDSON
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.