processo para fabricação de compostos de ciclopentilpirimidina hidroxilada

processo para fabricação de compostos de ciclopentilpirimidina hidroxilada

The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KEITH L. SPENCER, TRAVIS REMARCHUK, PETER J. STENGEL, SAGAR SHAKIA, JONATHAN W. LANE
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.