derivado do polímero da quitosana, composição farmacêutica, método para o tratamento, utilização e presente invenção

derivado do polímero da quitosana, composição farmacêutica, método para o tratamento, utilização e presente invenção

The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JAYNE CHIN, MATTHEW MICHAEL HAMILTON, ACHYUTHARAO SIDDURI, ROBERT ALAN GOODNOW JR
Format: Patent
Sprache:por
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (α4β1) and alpha-V-beta-3 (α Vβ3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.