composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral

composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral

The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: XIAOLAN ZHOU, KEITH SOO-NYUNG KWAK, HUIQUAN HAN, LEI-TING TONY TAM, JEONGHOON SUN
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.