inibição da expressão genética viral

this invention relates to modified short interfering rna (sirna) nucleic acid molecules, particularly sirna's which have been modified by the addition of a 2 -0- guanidinopropyl (gp) modified nucleoside. in particular the invention relates to modified sirnas which are capable of silencing targe...

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Bibliographische Detailangaben
Hauptverfasser:	STEFAN BERNHARDT, JOACHIM W. ENGELS, MAXIMILIAN C.R. BUFF, MUSA MARIMANI, ABDULLAH ELY, JENNIFER D'ONOFRIO, JUSTIN HEAN, JOLANTA BRZEZINSKA, PATRICK ARBUTHNOT
Format:	Patent
Sprache:	por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	this invention relates to modified short interfering rna (sirna) nucleic acid molecules, particularly sirna's which have been modified by the addition of a 2 -0- guanidinopropyl (gp) modified nucleoside. in particular the invention relates to modified sirnas which are capable of silencing target sequences, methods of treating and preventing infection by using the sirnas, medicaments containing the sirnas and use of the sirnas. _______________________________________________________________________ tradução do resumo resumo patente de invenção: "inibição da expressão genética viral". esta invenção refere-se às moléculas de ácido nucléico de rna interferente curto (sirna) modificado, em particular sirnas que foram modificados pela adição de um nucleosídeo modificado de 2-o-guanidinopropila (gp). em particular, a invenção refere-se aos sirnas modificados que são capazes de silenciar as sequências alvo, aos métodos de tratamento e prevenção da infecção através do uso dos sirnas, aos medicamentos contendo os sirnas e ao uso dos sirnas. This invention relates to modified short interfering RNA (siRNA) nucleic acid molecules, particularly siRNA's which have been modified by the addition of a 2-0-guanidinopropyl (GP) modified nucleoside. In particular the invention relates to modified siRNAs which are capable of silencing target sequences, methods of treating and preventing infection by using the siRNAs, medicaments containing the siRNAs and use of the siRNAs.