formulações e formas de dosagens de fosfolipídios oxidados

The current disclosure provides pharmaceutical compositions containing an oxidized phospholipid, such as 1-hexadecyl-2-(4′-carboxybutyl)-glycero-3-phosphocholine (VB-201) and a thermosoftening carrier, e.g., a poloxamer. The pharmaceutical competitions may further comprise an anti-adherent agent, su...

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Bibliographische Detailangaben
Hauptverfasser: VICTOR M YOUNG, MASSOUD BAKHSHAEE, IAN ROBERT WILDING, ALYN MCNAUGHTON, NAAMIT SHER
Format: Patent
Sprache:por
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Zusammenfassung:The current disclosure provides pharmaceutical compositions containing an oxidized phospholipid, such as 1-hexadecyl-2-(4′-carboxybutyl)-glycero-3-phosphocholine (VB-201) and a thermosoftening carrier, e.g., a poloxamer. The pharmaceutical competitions may further comprise an anti-adherent agent, such as talc and/or a thixotropic agent. The current disclosure further provides processes for preparing the pharmaceutical compositions. The disclosure further provides capsules containing the pharmaceutical compositions. Uses of such pharmaceutical compositions and capsules in treating inflammatory disorders are also disclosed.