antagonista de trpm8 e seu uso em tratamentos

Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders in...

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Bibliographische Detailangaben
Hauptverfasser:	KAUSTAV BISWAS, QINGYIAN LIU, JIAN J. CHEN, MATTHEW R. KALLER, CHESTER CHENGUANG YUAN, SCOTT HARRIED, VIJAY KESHAV GORE, JAMES BROWN, THOMAS T. NGUYEN, VU VAN MA, DANIEL B. HORNE, DAVID J. ST. JEAN JR, HOLGER MONENSCHEIN, WENGE ZHONG
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.