derivado de tetrahidroisoquinolina

[Problem] To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT 5A receptor regulating action. [Means for Solution] It was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N at...

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Hauptverfasser:	ISAO KINOYAMA, RYUICHI SEKIOKA, OSAMU KANEKO, TAKEHIRO MIYAZAKI, TAKUYA WASHIO, YOHEI KOGANEMARU, WATARU HAMAGUCHI
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	[Problem] To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT 5A receptor regulating action. [Means for Solution] It was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N atom of a tetrahydroisoquinoline ring or the like, and a cyclic group binds to an unsaturated ring has a potent 5-HT 5A receptor regulating action and an excellent pharmacological action based on the regulating action and also discovered that the tetrahydroisoquinoline derivative is useful as an agent for treating or preventing dementia, schizophrenia, and the like, whereby the present invention has been completed.