acoplamentos de peptídeo eficazes e uso dos mesmos na síntese e isolamento de um sal trissódico de ciclopen-ta[g]quinazolina

acoplamentos de peptídeo eficazes e uso dos mesmos na síntese e isolamento de um sal trissódico de ciclopen-ta[g]quinazolina

A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an...

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Hauptverfasser: SEAN MARK DALZIEL, THOMAS ELLIOTT JACKS, JAMES ALAN KERSCHEN, ALEXANDER JAMES BRIDGES, JAMES ROBERT ZELLER, MILIND D. CHOUBAL, ANDREW S. THOMPSON
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.