genes essenciais de cryptococcus

The present invention relates to methods for identifying and validating gene products from the Cryptococcus fungus as effective targets for therapeutic drug screening. The use of five genes identified in Cryptococcus, responsible for the production of nucleolar protein 16 (NOP16), a scramblase, otub...

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Bibliographische Detailangaben
Hauptverfasser:	RAFAEL SCHNEIDER, MÁRCIO L. RODRIGUES, CHARLEY CHRISTIAN STAATS, MARCIO L. RODRIGUES, LUNA SOBRINO JOFFE, MARILENE HENNING VAINSTEIN, LIVIA KMETZSCH ROSA E SILVA, AUGUSTO SCHRANK, LÍVIA KMETZSCH ROSA E SILVA
Format:	Patent
Sprache:	por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to methods for identifying and validating gene products from the Cryptococcus fungus as effective targets for therapeutic drug screening. The use of five genes identified in Cryptococcus, responsible for the production of nucleolar protein 16 (NOP16), a scramblase, otubain-1, beta DNA-polymerase and a hypothetical protein, proved to be useful for studying metabolic pathways for the growth, proliferation and survival of C. neoformans or C. gattii, for pigmentation, as well as the production of cellular or extracellular subproducts that are important for the pathogenicity and virulence of the microrganism. Cryptococcus wild-type strains or strains that suffered mutation for the interruption of genes were used to screen compounds with antifungal activity.