METHOD FOR THE PREPARATION OF N-METHYL-N-CYCLOHEXYL-(2-AMINO-3, 5-DIBROMBENZYL)-AMINHYDROCHLORIDE

METHOD FOR THE PREPARATION OF N-METHYL-N-CYCLOHEXYL-(2-AMINO-3, 5-DIBROMBENZYL)-AMINHYDROCHLORIDE

The synthesised compound is a broncholytic agent and is applicable in medicine. The yield thereafter is high and is within the prescribed prerequisites for environmental protection. According to the method, 2-nitrotoluol undergoes alkylation with N-methyl-N-cyclohexylamine to N-methyl-N-cyclohexyl-2...

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Hauptverfasser: RADOEVSKA, NADKA L, VLAKHOV, RADOSLAV J, TARPANOV, VELICHKO I, DAVKOV, DAVKO G, GEORGIEVA, GENOVEVA S, PENKOV, MIKHO D, USHATOVA, VALENTINA A
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The synthesised compound is a broncholytic agent and is applicable in medicine. The yield thereafter is high and is within the prescribed prerequisites for environmental protection. According to the method, 2-nitrotoluol undergoes alkylation with N-methyl-N-cyclohexylamine to N-methyl-N-cyclohexyl-2-nitrobenzylamine, reduction with ammonium sulphide, followed by bromation of the prepared product with hydrobromic acid to N-methyl-N-cyclohexyl-(2-amino-3,5-dibrombenzyl)-amine, which is isolated as hydrochloric salt.