МЕТОД ЗА ПОЛУЧАВАНЕ НА НОВИ ПРОИЗВОДНИ НА ФЕНОТИАЗИНА

Compounds of the general formula and their salts with pharmacologically acceptable acids, where R is methyl or ethyl and n is 2 or 3 are prepared by reacting (a) a phenothiazine of the formula where X is the residue of a reactive ester with an imidazolidone of the formula or (b) 3-chlorophenothiazine with an imidazolidone of the formula at an elevated temperature; or (c) a phenothiazine compound of the formula with an imidazolidone derivative of the formula at an elevated temperature and in the presence of an acid binding agent. N - [b - (1 - Methyl and 1 - ethyl - 2 - oxoimidazolidyl)-ethyl and propyl] piperazines are prepared by reacting the 1-alkyl-3-b -chloroethyl - imidazolidone - (2) with mono carbethoxypiperazine and decarboxylating the N-carbethoxypiperazine derivative formed.ALSO:Pharmaceutical compositions comprise compounds of the formula or their salts with pharmacologically acceptable acids, wherein n is 2 or 3 and R is methyl or ethyl, and an inert carrier or diluent. Examples are given of parenteral administration of the compositions and of the naicosis prolonging effect on previously administered hexobarbital -Na.