PHARMACEUTICAL PIPERAZINE COMPOUNDS

Пиперазиндионът има обща формула@@в която заместителите имат посочените в описанието значения. Съединенията съгласно изобретението се използват като модулатори на полилекарствена резистентност. Piperazinedion having the general formulawhere R1 is selected from hydrogen, group with the formula of-(NH)t-COR3 where t has the value of 0 and R3 is selected fromwhere v has the value 0, when t is 1, and v is 1 when t is 0, nhaving the value of 1 to 0 and m - 0, 1, 2 or 3, when at least oneof n and m is different from 0: (a) R4 is H or C1-C6 alkyl and R5is C1-C6 alkyl, optionally substituted by one or two phenylgroups, the phenyl group or groups are optionally substituted byone or two C1-C6 alkoxygroups, and (b) R4 and R5 together with anitrogen atom to which are heterocyclic group is bound selectedfrom (1) to (4)R6 and R7 being the same or different, are H or C1-C6 alkoxy or R6and R7, forming togehter a methylenedioxygroup, Y is 0 or -NR8, R8being C1-C6 alkyl or phenyl group, optionally substituted by CF3;p being 1 or 2 and Z being C2-C6 alkenyl or phenyl group,optionally substituted by C1-C6 alkoxy; andR9 is C1-C6 alkyl, pyrimidine or phenyl group, optionally selectedfrom C1-C6 alkoxy; andwhen W is 1, 2 or 3 and L is heterocyclic group or formula 1 asindicated above; group with formulawhere every of R10 and R11, which can be the same or different, isC1-C6 alkyl; and group with the formulawhere S is 0 or 1 and every r, which can be the same or different,is 1, 2 or 3 and L is heterocyclic group with the above formula 1and R2 is hydrogen or group with formula -COR3, as indicated,ensuring that one of R1 or R2 is hydrogen or is not hydrogen, orits pharmaceutically acceptable salt. The compound is used as amodulator of polymedicamentous resistence.