METHOD FOR THE PREPARATION OF LOVASTATIN
Методът намира приложение във фармацевтичната промишленост. Полученият ловастатин е с повишени чистота и добив и е стабилен при съхранение. Извлича се чрез филтруване от културалната течност при стойност на рН от 9,5 до 13,0 и се утаява от филтрата,включен в твърда маса, при рН 2-4 в присъствие наин...
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| creator | PETKOV, NEDELCHO G DIMOV, DIMCHO I TODOROVA, DIMITRA TS GROZDANOV, GEORGI A |
| description | Методът намира приложение във фармацевтичната промишленост. Полученият ловастатин е с повишени чистота и добив и е стабилен при съхранение. Извлича се чрез филтруване от културалната течност при стойност на рН от 9,5 до 13,0 и се утаява от филтрата,включен в твърда маса, при рН 2-4 в присъствие наинертен пълнител, антиоксидант и 0,1-3% органиченразтворител, несмесващ се с вода. Екстрахира се исе лактонизира в среда от хлоросъдържащ разтворител. Последният се концентрира, а остатъкът се разтваря в смес от разтворители с различна полярност. При охлаждане от -10 до -300С ловастатинът изкристализира, изолира се и се суши.
The method is used in the pharmaceutical industry. The lovastatin produced has higher purity and yield, and is stable during storage. It is extracted by filtration from the cultural liquor at pH values from 9.5 to 13.0 and is sedimented from the filtrate included in solid mass at pH 2-4 in the presence of inert filler, antioxidant and 0.1-3% organic solvent which does not mix in water. It is extracted and lactonized in chlorine-containing solvent medium. The latter is concentrated and the residue is dissolved in a mixture of solvents of different polarity. In cooling from -10 to -30°C the lovastatin crystallizes. is isolated and is dried. |
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The method is used in the pharmaceutical industry. The lovastatin produced has higher purity and yield, and is stable during storage. It is extracted by filtration from the cultural liquor at pH values from 9.5 to 13.0 and is sedimented from the filtrate included in solid mass at pH 2-4 in the presence of inert filler, antioxidant and 0.1-3% organic solvent which does not mix in water. It is extracted and lactonized in chlorine-containing solvent medium. The latter is concentrated and the residue is dissolved in a mixture of solvents of different polarity. In cooling from -10 to -30°C the lovastatin crystallizes. is isolated and is dried.</description><edition>6</edition><language>bul ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970731&DB=EPODOC&CC=BG&NR=100316A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970731&DB=EPODOC&CC=BG&NR=100316A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PETKOV, NEDELCHO G</creatorcontrib><creatorcontrib>DIMOV, DIMCHO I</creatorcontrib><creatorcontrib>TODOROVA, DIMITRA TS</creatorcontrib><creatorcontrib>GROZDANOV, GEORGI A</creatorcontrib><title>METHOD FOR THE PREPARATION OF LOVASTATIN</title><description>Методът намира приложение във фармацевтичната промишленост. Полученият ловастатин е с повишени чистота и добив и е стабилен при съхранение. Извлича се чрез филтруване от културалната течност при стойност на рН от 9,5 до 13,0 и се утаява от филтрата,включен в твърда маса, при рН 2-4 в присъствие наинертен пълнител, антиоксидант и 0,1-3% органиченразтворител, несмесващ се с вода. Екстрахира се исе лактонизира в среда от хлоросъдържащ разтворител. Последният се концентрира, а остатъкът се разтваря в смес от разтворители с различна полярност. При охлаждане от -10 до -300С ловастатинът изкристализира, изолира се и се суши.
The method is used in the pharmaceutical industry. The lovastatin produced has higher purity and yield, and is stable during storage. It is extracted by filtration from the cultural liquor at pH values from 9.5 to 13.0 and is sedimented from the filtrate included in solid mass at pH 2-4 in the presence of inert filler, antioxidant and 0.1-3% organic solvent which does not mix in water. It is extracted and lactonized in chlorine-containing solvent medium. The latter is concentrated and the residue is dissolved in a mixture of solvents of different polarity. In cooling from -10 to -30°C the lovastatin crystallizes. is isolated and is dried.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDwdQ3x8HdRcPMPUgjxcFUICHINcAxyDPH091Pwd1Pw8Q9zDA4Bcv14GFjTEnOKU3mhNDeDnJtriLOHbmpBfnxqcUFicmpeakm8k7uhgYGxoZmjMUEFADXlIrc</recordid><startdate>19970731</startdate><enddate>19970731</enddate><creator>PETKOV, NEDELCHO G</creator><creator>DIMOV, DIMCHO I</creator><creator>TODOROVA, DIMITRA TS</creator><creator>GROZDANOV, GEORGI A</creator><scope>EVB</scope></search><sort><creationdate>19970731</creationdate><title>METHOD FOR THE PREPARATION OF LOVASTATIN</title><author>PETKOV, NEDELCHO G ; DIMOV, DIMCHO I ; TODOROVA, DIMITRA TS ; GROZDANOV, GEORGI A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BG100316A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>bul ; eng</language><creationdate>1997</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PETKOV, NEDELCHO G</creatorcontrib><creatorcontrib>DIMOV, DIMCHO I</creatorcontrib><creatorcontrib>TODOROVA, DIMITRA TS</creatorcontrib><creatorcontrib>GROZDANOV, GEORGI A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PETKOV, NEDELCHO G</au><au>DIMOV, DIMCHO I</au><au>TODOROVA, DIMITRA TS</au><au>GROZDANOV, GEORGI A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR THE PREPARATION OF LOVASTATIN</title><date>1997-07-31</date><risdate>1997</risdate><abstract>Методът намира приложение във фармацевтичната промишленост. Полученият ловастатин е с повишени чистота и добив и е стабилен при съхранение. Извлича се чрез филтруване от културалната течност при стойност на рН от 9,5 до 13,0 и се утаява от филтрата,включен в твърда маса, при рН 2-4 в присъствие наинертен пълнител, антиоксидант и 0,1-3% органиченразтворител, несмесващ се с вода. Екстрахира се исе лактонизира в среда от хлоросъдържащ разтворител. Последният се концентрира, а остатъкът се разтваря в смес от разтворители с различна полярност. При охлаждане от -10 до -300С ловастатинът изкристализира, изолира се и се суши.
The method is used in the pharmaceutical industry. The lovastatin produced has higher purity and yield, and is stable during storage. It is extracted by filtration from the cultural liquor at pH values from 9.5 to 13.0 and is sedimented from the filtrate included in solid mass at pH 2-4 in the presence of inert filler, antioxidant and 0.1-3% organic solvent which does not mix in water. It is extracted and lactonized in chlorine-containing solvent medium. The latter is concentrated and the residue is dissolved in a mixture of solvents of different polarity. In cooling from -10 to -30°C the lovastatin crystallizes. is isolated and is dried.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE |
| title | METHOD FOR THE PREPARATION OF LOVASTATIN |
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