ANALOGUES CYCLIQUES D'UNE PEPTIDE NATUREL STIMULANT LA PHAGOCYTOSE, ET SON PROCEDE DE PREPARATION

PCT No. PCT/SU80/00060 Sec. 371 Date Dec. 12, 1980 Sec. 102(e) Date Dec. 12, 1980 PCT Filed Apr. 2, 1980 PCT Pub. No. WO80/02141 PCT Pub. Date Oct. 16, 1980.A novel substance, that is a cyclic analogue of a naturally-occurring phagocytosis-stimulant peptide - threonyl-cyclo-[-N epsilon -lysyl-prolyl...

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Hauptverfasser:	N.I. VERETENNIKOVA, Z.A. ATARE, G.I. CHIPENS
Format:	Patent
Sprache:	fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/SU80/00060 Sec. 371 Date Dec. 12, 1980 Sec. 102(e) Date Dec. 12, 1980 PCT Filed Apr. 2, 1980 PCT Pub. No. WO80/02141 PCT Pub. Date Oct. 16, 1980.A novel substance, that is a cyclic analogue of a naturally-occurring phagocytosis-stimulant peptide - threonyl-cyclo-[-N epsilon -lysyl-prolyl-arginyl-] of the formula: A method for preparing threonyl-cyclo-[-N epsilon -lysyl-prolyl-arginyl-] by way of a step-wise building-up of the peptide chain from the C-terminal by means of activated ethers of benzyloxycarbonyl-proline, tert.butyloxycarbonyl- -N epsilon -benzyl-oxycarbonyl-lysine and tert.butyloxycarbonyl-threonine, followed by cyclization of the resulting partly blocked tetrapeptide using Woodward reagent in an excess of dimethylformamide and isolation of the desired product.